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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Biochem Pharmacol. 2019 Jan 30;163:21–31. doi: 10.1016/j.bcp.2019.01.022

Figure 5. CPA- and CP-532,903-elicted IKATP are blocked by treatment with pertussis toxin.

Figure 5.

Representative whole-cell currents recorded from pertussis toxin-treated cardiomyocytes (2 μg/ml for a minimum of 1 h) isolated from wild-type C57Bl/6 mice after application of CPA (1 μM; A) or CP-532,903 (1 μM; B). Both agonists failed to significantly elicit IKATP after pertussis toxin treatment. Similar results were obtained in recordings from 4–6 additional cells per treatment group. All recordings were obtained as described in METHODS in the presence of ZM241385 (100 nM) and PSB603 (100 nM) to block A2A and A2BARs.