Table 3.

Functional parameters of isolated hearts at baseline and after infusion of CP-532,903 or vehicle while pacing at 420 beats/min.

Genotype	N	Treatment	Devel. Pressure (mmHg)	+dP/dt (mmHg/s)	−dP/dt (mmHg/s)	Coronary Flow (ml/min/g)
Adora3LoxP/LoxP	Male = 9	baseline	93.3 ± 2.0	3,704 ± 263	−2,006 ± 406	22.4 ± 1.8
	Female = 4	vehicle	94.9 ± 1.8	3,765 ± 253	−1,985 ± 401	22.1 ± 2.0
	Total = 13
	Male = 7	baseline	86.5 ± 3.5	3,098 ± 467	2,254 ± 118	23.1 ± 1.1
	Female = 3	CP-532,903	86.2 ± 3.2	3,238 ± 476	2,273 ± 116	22.3 ± 1.0
	Total = 10
Adora3LoxP/LoxP;Myh6-Cre	Male = 7	baseline	79.2 ± 7.0	3,248 ± 408	−2,108 ± 226	21.9 ± 1.1
	Female = 6	vehicle	80.5 ± 6.7	3,299 ± 390	−2,127 ± 229	21.0 ± 0.9
	Total = 13
	Male = 7	baseline	88.6 ± 1.8	3,553 ± 197	−2,249 ± 111	25.2 ± 1.8
	Female = 6	CP-532,903	88.8 ± 1.9	3,571 ± 192	−2,255 ± 112	24.6 ± 2.1
	Total = 13