Table 2.

Comprehensive characterization of cuprizone short-term exposure (CSE) mice and maternal immune activation (MIA) mice

Stress signals/Behavioral dimensions		Index	Tests	Results CSE		MIA (GD9, 5 mg/kg i.v. or GD9.5, 20 mg/kg i.p.)
Stress signals	Inflammation	TSPO levels IL-6 levels		↑ ↑	Fig.1 [10]	↓ ↑	[12] [12]
	HPA axis	Serum corticosterone levels		↑	Fig. 2A	↑	Fig. 2B
	Oxidative stress	Protein carbonylation levels		→	Fig. 3A	↓	Fig. 3B
Behavioral dimensions	Psychosis	Sensitivity to psychostimulants	OF	↑	[10] [11]	↑	[13]
	Memory	Spatial learning and memory Recognition memory Spontaneous alternation Context/cue-associated fear learning and memory Avoidance learning	MWM NORT Y-maze FC AAL	ND ↓ ↓ Normal ND	[10] [10] [11]	Normal ND ↓ ND ↓	[14] [15] [13]
	Executive function	Behavioral flexibility	RL	Normal	[11]	Normal	[16]
	Social cognition	Sociability/social novelty	SIT	Normal	[11]	↓	[12]
	Anxiety	Neophobia Hyponeophagia Exploration based conflict	LDT NSFT OF	↑ Normal ND	[11] [11]	ND ND ↑	[16]
	Depression	Behavioral despair	FST/TST	Normal	[11]	ND
	Information processing	Sensorimotor gating	PPI	Normal	[10]	↓	[12]
	Attention	Latent inhibition	LI	ND		↓	[13]
	Motor systems	Motor coordination/learning	Rotarod	Normal	[11]	ND

[10] Tezuka et al. 2013, [11] Kondo et al. 2016, [12] Notter et al. 2017, [13] Meyer et al., 2005, [14] Meyer et al., 2008, [15] Willi et al., 2013, [16] Meyer et al., 2006

GD, gestation day; TSPO, Translocator protein 18kDa; IL-6, Interleukin-6; HPA, Hypothalamic-pituitary-adrenal; OF, Open field; MWM, Morris water maze; ND, not determined; NORT, Novel object recognition test; FC, Fear conditioning; AAL, Active avoidance test; RL, Reversal learning; SIT, Social interaction test; LDT, Light/dark box test; NSFT, Novelty suppressed feeding test; FST, Forced swim test; TST, Tail suspension test; PPI, Prepulse inhibition; LI, Latent inhibition