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. Author manuscript; available in PMC: 2019 Dec 21.
Published in final edited form as: ACS Chem Biol. 2018 Nov 28;13(12):3361–3373. doi: 10.1021/acschembio.8b00867

Figure 1. ZMA biosynthesis by the PKS/NRPS hybrid pathway.

Figure 1.

Each module is shown with the cognate building block tethered to the carrier protein. The pathway produces two metabolites (not shown), one of which is a prodrug that is cleaved to yield the active product, ZMA. The trans-AT ZmaF transfers an AmM extender unit to ZmaA-ACP1 through an ACP-linked extender unit, AmM-ZmaH. The subsequent PKS module also utilizes an ACP-linked extender unit (hydroxymalonyl-ZmaD) through the cis-AT, ZmaA-AT.