Figure 1:

Computational model reactions, schematics, and validation. (A) Model schematic showing reactive species and bound complexes. F = FGF2, R = FGFR, H = HSPG, FR = FGF2-FGFR, FH = FGF2-HSPG, FHR = FGF2-HSPG-FGFR (triad), BM = basement membrane. The subscript i indicates internalized species. (B) Computational model geometry showing parallel plate flow chamber and bottom reactive boundary with uniform H and R distribution. (C) Model validation at 4° C. Increasing cell surface HSPG concentration leads to increased FHR formation and decreased FR.