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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Ann Biomed Eng. 2019 Jan 28;47(4):1078–1093. doi: 10.1007/s10439-019-02202-7

Figure 3:

Figure 3:

Increased cell surface HSPG concentration increased FGF2-HSPG (FH) complexes and decreased FGF2-FGFR (FR) complexes but did not affect FGF2-HSPG-FGFR (HFR) complexes. (A) Predicted values of FH, FR, FHR, and FR+FHR as HSPG concentration was increased from 2.16 × 10−13 to 2.16 × 10−7 mol/m2 (α=1; ki,H, ksH, koFH at base values). (B) FGFR state as free FGFR (no bound FGF2), FGF2 bound FGFR (FR+FHR) and total FGFR with increasing HSPG concentration.. (C) FGFR internalization as free FGFR (R), FGF2-FGFR (FR), and FGF2-HSPG-FGFR (FHR) with increasing HSPG concentration. Flow rate 2.1 mL/min; [FGF2] = 10 ng/mL (5.56 × 10−5 µM); [FGFR] = 4.15 × 10−12 mol/m2.