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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Ann Biomed Eng. 2019 Jan 28;47(4):1078–1093. doi: 10.1007/s10439-019-02202-7

Figure 4:

Figure 4:

HSPG production, internalization, and FGF2-HSPG dissociation rate had the largest effect on cell surface bound FGF2. Bound FGF2 as FGF2-HSPG (FH), FGF2-FGFR (FR), and FGF2-HSPG-FGFR (FHR) with varied (A) HSPG production rate (PH) from 1.14 × 10−14 to 1.14 × 10−10 mol/m2min−1 (α=1; ki,H, ksH, koFH at base values); (B) HSPG availability (α) from 0 to 1 in 0.1 intervals (PH, ki,H, ksH, koFH at base values); (C) HSPG internalization rate (ki,H) from 3.17 × 10−4 to 3.17 × 100 min−1 (α=1; PH, ksH, koFH at base values); (D) HSPG shedding rate (ksH) from 5.84 × 10−7 to 5.84 × 10−1 min−1 (α=1; PH, ki,H, koFH at base values); and (E) FH dissociation rate (ko,FH) from 1.37 × 10−2 to 1.37 × 102 min−1 (α=1; PH, ki,H, ksH at base values). Initial model values: [FGF2] = 10 ng/mL (5.56 × 10−5 µM); [HSPG] =2.16 × 10−10 mol/m2; [FGFR] = 4.15 × 10−12 mol/m2; flow rate = 2.1 mL/min; simulation time = 300 min. Base values are indicated by dotted lines.