Table 1.

Base model parameter values

Model Geometry
H	1.27 × 10−4 m	Height of the chamber	Text
L	0.01 m	Width of chamber	Text
HBM	5 × 10−8 m	BM thickness	32,64
Initial Concentration
F0	10 ng/ml (5.56 × 10−4 µM)	FGF2 Concentration	Text
R0	4.15 × 10−12 mol/m2	FGFR Concentration	32,65
H0	2.16 × 10−10 mol/m2	HSPG Concentration	32,65
H0, BM	4.48 × 10−8 mol/m2	BM HSPG Concentration	32,66
F0, BM	1.74 × 10−14 mol/m2	BM FGF2 basal concentration	32
Diffusion Properties
DF	1.32 × 10−8 m2/min	FGF2 Diffusivity	32,35
Surface Binding
kon,FR	4.2 × 102 μM−1 min−1	Association FGF2-FGFR	32,35
koff,FR	0.79 min−1	Dissociation FGF2-FGFR	32,35
kon,FH	1.2 × 102 μM-1 min−1	Association FGF2-HSPG	32,35
koff,FH	1.37 min−1	Dissociation FGF2-HSPG	32,35
kon,FHR	1 × 108 (µmol/cm2)−1 min−1	Association FGF2-HSPG-FGFR	35
koff,FHR	0.038 min−1	Dissociation FGF2-HSPG-FGFR	32,35
ks,H	5.84 × 10−4 min−1	HSPG shedding from cell surface	36
Internalization
ki,R	0.005 min−1	Internalization FGFR	32,35
ki,H	0.0317 min−1	Internalization HSPG	36,67
ki,FR	0.078 min−1	Internalization FGF2-FGFR	32,35
ki,FH	0.0048 min−1	Internalization FGF2-HSPG	68
ki,FHR	0.043 min−1	Internalization FGF2-HSPG-FGFR	32,35
Production
PR	ki,R*R0	Production FGFR	32,35
PH	ki,H*H0	Production HSPG	32,35
Degradation
kd,H	5 × 10−3 min−1	Degrade HSPG	32,35
kd,FR	20 × 10−3 min−1	Degrade FGF2-FGFR	32,35
kd,FH	5.6 × 10−3 min−1	Degrade FGF2-HSPG	32,35
kd,FHR	5.6 × 10−3 min−1	Degrade FGF2-HSPG-FGFR	32,35
Basement Membrane
kp	7.2 × 10−7 m/min	BM Permeability	32
kon,BM	25.2 μM−1 min−1	Association FGF2-HSPG in BM	69
kon,BM	0.6 min−1	Dissociation FGF2-HSPG in BM	69
α	1	Total HSPG Availability	Text