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. 2019 Mar 20;20(5):801–811. doi: 10.3348/kjr.2018.0453

Fig. 3. Nineteen=year-old male with osteosarcoma and histopathology of good responses to neoadjuvant chemotherapy.

Fig. 3

Images before (A–F) and after (G–L) chemotherapy are shown. Compared to pre-chemotherapy, tumor size decreased on axial fat-saturated T2WI (B–H) whereas intramedullary extension changed little on coronal T1WI (A, G). ADC value significantly increased from 0.89 × 10−3 mm2/s to 1.72 × 10−3 mm2/s (C, I), whereas MK values significantly decreased from 0.93 to 0.53 (D, J). MD value also significantly increased from 1.26 × 10−3 mm2/s to 2.33 × 10−3 mm2/s (E, K). F. Photomicrography (HE, × 200) showed osteosarcoma with CT-guided biopsy before chemotherapy. L. Photomicrography (HE, × 200) depicts tumor necrosis rate of approximately 95% after chemotherapy.