Table 3. Association between Diffusion Parameters and Pathologic Diagnoses.
Parameter (x 10-3 mm2/sec) | ADC | Ds | Df | f* | DDC | α* | MD | MK* |
---|---|---|---|---|---|---|---|---|
Benign (n = 18) | 0.0010 (0.0004) | 0.0010 (0.0004) | 0.0138 (0.0414) | 0.2300 (0.1400) | 0.0016 (0.0023) | 0.4450 (0.1600) | 0.0022 (0.0013) | 0.9750 (0.2900) |
Malignant (n = 63) | 0.0015 (0.0006) | 0.0015 (0.0006) | 0.0087 (0.0135) | 0.2300 (0.1900) | 0.0023 (0.0014) | 0.6800 (0.1300) | 0.0027 (0.0012) | 0.6660 (0.3000) |
p† | 0.003 | 0.001 | 0.388 | 0.959 | 0.578 | < 0.001 | 0.420 | < 0.001 |
ccRCC (n = 46) | 0.0016 (0.0004) | 0.0016 (0.0004) | 0.0095 (0.0172) | 0.3250 (0.1800) | 0.0024 (0.0005) | 0.6550 (0.1400) | 0.0028 (0.0006) | 0.6200 (0.1800) |
Non-ccRCC (n = 17) | 0.0010 (0.0004) | 0.0010 (0.0005) | 0.0078 (0.0124) | 0.1500 (0.1300) | 0.0012 (0.0005) | 0.7000 (0.0700) | 0.0016 (0.0007) | 0.9000 (0.1600) |
p† | < 0.001 | < 0.001 | 0.143 | < 0.001 | < 0.001 | 0.112 | < 0.001 | < 0.001 |
Low-grade (n = 39) | 0.0017 (0.0003) | 0.0017 (0.0003) | 0.0087 (0.0170) | 0.3300 (0.1700) | 0.0025 (0.0006) | 0.6700 (0.1400) | 0.0028 (0.0006) | 0.6000 (0.1900) |
High-grade (n = 7) | 0.0014 (0.0005) | 0.0011 (0.0007) | 0.0116 (0.0224) | 0.2200 (0.1900) | 0.0021 (0.0014) | 0.6000 (0.1300) | 0.0028 (0.0010) | 0.7500 (0.1600) |
p† | 0.018 | 0.010 | 0.291 | 0.183 | 0.087 | 0.076 | 0.291 | 0.002 |
Data are medians with interquartile range in parentheses. *f, α, and MK have no units, †p value from statistical comparison between benign and malignant lesions, between ccRCC and non-ccRCC, between low-grade and high-grade ccRCC, respectively, by using Mann-Whitney U test. ADC = apparent diffusion coefficient, ccRCC = clear cell renal cell carcinoma, DDC = distributed diffusion coefficient, Df = fast diffusion coefficient, Ds = slow diffusion coefficient, f = fraction of fast diffusion, MD = mean diffusivity, MK = mean kurtosis, α = anomalous exponent term