Table 4. Diagnostic Performance in Overall and Subgroup Analysis for Evaluating Pathologic Fractures in Two Readers Using 5-Point Scale.
| CE set (%) | DW set (%) | Combined set (%) | P | |||
|---|---|---|---|---|---|---|
| CE set vs. DW set | DW set vs. Combined set | CE set vs. Combined set | ||||
| Overall (n = 98) | ||||||
| Reader 1 | ||||||
| Sensitivity | 98.0 | 93.9 | 98.0 | 0.63 | 0.50 | 1.0 |
| Specificity | 71.4 | 81.6 | 93.9 | 0.36 | 0.07 | 0.001* |
| Accuracy | 84.7 | 87.8 | 95.9 | 0.21 | 0.34 | 0.003* |
| Reader 2 | ||||||
| Sensitivity | 98.0 | 95.9 | 94.9 | 1.00 | 1.00 | 0.63 |
| Specificity | 85.7 | 89.8 | 98.0 | 0.73 | 0.13 | 0.07 |
| Accuracy | 91.8 | 92.9 | 95.9 | 0.55 | 0.13 | 0.04* |
| Single bone abnormality (n = 25) | ||||||
| Reader 1 | ||||||
| Sensitivity | 93.7 | 93.8 | 100.0 | 1.00 | 1.00 | 1.0 |
| Specificity | 44.4 | 77.8 | 77.8 | 0.38 | 1.00 | 0.25 |
| Accuracy | 76.0 | 88.0 | 92.0 | 0.45 | 1.00 | 0.63 |
| Reader 2 | ||||||
| Sensitivity | 93.8 | 93.8 | 100.0 | 1.00 | 1.00 | 1.0 |
| Specificity | 77.8 | 88.9 | 100.0 | 1.00 | 1.00 | 0.5 |
| Accuracy | 88.0 | 92.0 | 100.0 | 1.00 | 1.00 | 1.0 |
| Absent extra-osseous soft tissue component (n = 82) | ||||||
| Reader 1 | ||||||
| Sensitivity | 97.1 | 91.2 | 97.1 | 0.63 | 0.50 | 1.0 |
| Specificity | 72.9 | 83.3 | 95.8 | 0.36 | 0.07 | 0.001* |
| Accuracy | 82.9 | 86.6 | 96.3 | 0.21 | 0.34 | 0.003* |
| Reader 2 | ||||||
| Sensitivity | 97.1 | 94.1 | 91.2 | 1.00 | 1.00 | 0.63 |
| Specificity | 85.4 | 89.6 | 98.0 | 0.73 | 0.13 | 0.07 |
| Accuracy | 90.2 | 91.5 | 95.1 | 0.55 | 0.13 | 0.039* |
| Present fracture site enhancement (n = 90) | ||||||
| Reader 1 | ||||||
| Sensitivity | 98.0 | 93.9 | 98.0 | 0.63 | 0.50 | 1.0 |
| Specificity | 68.3 | 80.5 | 92.7 | 0.33 | 0.13 | 0.002* |
| Accuracy | 84.4 | 87.8 | 95.6 | 0.19 | 0.51 | 0.006* |
| Reader 2 | ||||||
| Sensitivity | 98.0 | 95.9 | 93.9 | 1.00 | 1.00 | 0.63 |
| Specificity | 83.0 | 90.2 | 97.6 | 0.45 | 0.25 | 0.07 |
| Accuracy | 91.1 | 93.3 | 95.6 | 0.34 | 0.22 | 0.04* |
*Indicated significant difference between two groups. CEFST1 = contrast-enhanced fat-saturated T1-weighted imaging, CE set = NEMR plus CEFST1, Combined set = DWI plus NEMR plus CEFST1, DW set = DWI plus NEMR, NEMR = non-enhanced MRI