Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 17;9:6194. doi: 10.1038/s41598-019-42517-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

NDV-3A vaccination prevents infection of central venous catheters in vivo, and prevents C. albicans virulence traits in vitro. Vaccination of jugular vein catheterized mice with NDV-3A significantly enhanced anti-rAls3p-N antibodies titers (A). Vaccination protected immunized mice from C. albicans infection of jugular vein catheters by ~1.5 log (p = 0.04) versus the placebo mice, and significantly (p = 0.0006) reduced the fungal burden in mice kidneys after three days, compared to alum-vaccinated mice (B). C. albicans pretreated with NDV-3A or placebo antiserum were incubated with HUVEC cells for 90 min, and the number of cells invading the host cells quantified (C). Serum-pretreated C. albicans cells were also allowed to develop a biofilm for 24 h, and biofilm metabolic activity quantified by XTT assay (D).