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. 2019 Apr 17;9:6195. doi: 10.1038/s41598-019-42643-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of ITGA2 as a molecular target for GBM. (a) Surface protein expression profile of 70 cancer-related antigens in three human GBM cell lines and normal SVG-P12 cells. (b) Venn diagram indicating ITGA2 co-overexpressed by three GBM cell lines in reference to SVG-P12 cells. (c) Cell membrane expression levels of ITGA2 and EGFR in GBM and SVG-P12 cells using flow cytometry analysis, showing increased tumor-specificity of ITGA2 expression on GBM cells as compared to both control cells and also to the current GBM marker, EGFR. (d) Representative microscopic images of immunofluorescent staining of ITGA2 in GBM and SVG-P12 cells. Scale bars represent 50 µm. (e) ITGA2 mRNA expression levels in human GBM tumor tissues and normal brain tissues. **P < 0.001. (f) Correlation between overall survival and ITGA2 mRNA expression levels in GBM patients as determined via Kaplan-Meier analysis (Log-rank test). Data of (e) and (f) were obtained from the R2: Genomics Analysis and Visualization Platform database.