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. 2019 Apr 17;4(2):e00154-19. doi: 10.1128/mSphereDirect.00154-19

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Copyright © 2019 Wong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Systemic analysis of genes differentially expressed between in vivo and in vitro growth conditions of B. pertussis. (A) Total number of genes statistically activated or repressed in a comparison of B. pertussis growing in SSM (in vitro) to B. pertussis growing in NSG mice. (B) Predicted cellular localization of differentially expressed genes, according to the color scheme of panel A. (C) Numbers of virulence-activated genes (VAGs) and virulence-repressed genes (VRGs) in vivo compared to numbers in vitro revealed low correlation with Bvg designations. B. pertussis VAGs and VRGs were determined based on the study performed by Moon et al. (26).