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Volcano plot indicating B. pertussis gene expression in the infected lung compared to expression in vitro. Yellow denotes significant activated genes, and green indicates significant repressed genes. Virulence-activated genes (VAGs) are denoted by triangles and virulence-repressed genes (VRGs) are denoted by squares. Genes that are independent of the BvgAS system are shown with circles. B. pertussis VAGs and VRGs were determined based on the study performed by Moon et al. (26).
