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. 2019 Apr 11;10:704. doi: 10.3389/fimmu.2019.00704

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Copyright © 2019 Brandsma, Bondza, Evers, Koutstaal, Nederend, Jansen, Rösner, Valerius, Leusen and ten Broeke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blocking FcγRIIIb only marginally improves tumor cell lysis. (A) Quantitative expression of FcγR and FcαRI on human neutrophils as analyzed by flow cytometry (Qifikit), n = 6–11 healthy donors. (B) 3 h ⁵¹Cr release assays using EL4-CD20 with anti-CD20 IgA2 or IgG1 (rituximab), SK-BR-3 with anti-HER2 IgA1 or IgG1 and A431 with anti-EGFR IgA2 or IgG1, all at 10 ug/mL. 3G8 F(ab′)₂ fragments (1 ug/mL final concentration) were added 15 min prior to start of the ADCC assays. Statistics: one-way ANOVA with Tukey's multiple comparison test, p < 0.05: ^*, p < 0.01: ^**, p < 0.0001: ^****. Ctrl indicates no antibody added.