Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 11;9:211. doi: 10.3389/fonc.2019.00211

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Liu, Wang, Jiang, Zhang, Zhu, Lin, Jiang, Lin, Xiao, Fang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

HDGF expression knockdown decreases cell migration, invasion, and metastasis. Stable downregulation of HDGF reduced the in vitro migration ability of Ishikawa and RL95-2 cells (A). The wound healing assay indicated that shHDGF transfection into Ishikawa and RL95-2 cells for 48 h impaired migration capacity compared with the negative control group (B). Stable suppression of HDGF reduced the in vitro invasiveness of shHDGF-Ishikawa and shHDGF-RL95-2 cells (C). In vivo intrahepatic metastasis assay results after shHDGF-Ishikawa and PLV-Ctr-Ishikawa injection: PLV-Ctr-EC cells were more easily transferred to intestinal tissue (D). The HE (E) and IHC (F) of the metastatic intestinal tissues. Original magnification 200×. The numbers of metastatic tumors (G). Data are presented as the mean ± SD for three independent experiments. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, statistically significant difference.