Figure 5.

Microdialysis experiments. Coronal section diagrams modified from Franklin and Paxinos (2007) and a representative photomicrograph illustrating the reconstructed tip of the probe placement and the track left by the microdialysis probe in the brain tissue, respectively in the nucleus accumbens (A). Effect of subcutaneous injection of vehicle or a low dose (10 mg/kg, B) and high dose (100 mg/kg, C) of rac-CE-123 or S-CE-123 on DA levels in dialysates from the nucleus accumbens of mice. Dopamine values in microdialysates are shown as changes in basal DA values, calculated as the mean of three consecutive samples immediately preceding the drug or vehicle injection. Data are expressed as mean ± SEM. n = 6 per group; **p < 0.01 vs. respective value in the vehicle-treated controls (two-way ANOVA followed by Fisher’s post hoc test).