Table 2.
Experimental subject’s latency to investigate and duration of aggressive behavior (means in seconds + SEM) towards the presented stimulus animal measured during the 1st and 2nd sampling, respectively.
| Si | Parameter | 1st sampling | 2nd sampling | ANOVA | ||
|---|---|---|---|---|---|---|
| Vehicle | Drug | Vehicle | Drug | |||
| rac-CE-123 (retroactive) | ||||||
| 3 h | Latency | 5.50 + 2.08 | 3.45 + 0.85 | 28.13 + 11.07 | 18.16 + 11.21 | F(3,64) = 2.11; p = 0.11 |
| Aggression | 3.25 + 0.71 | 3.80 + 1.14 | 2.19 + 1.00 | 5.14 + 1.42 | F(3,64) = 1.25; p = 0.30 | |
| 6 h | Latency | 8.62 + 2.38 | 2.46 + 0.44 | 21.90 + 7.39 | 10.41 + 1.79 | F(3,72) = 4.49; P < 0.01 |
| Aggression | 2.59 + 1.04 | 1.62 + 0.50 | 1.90 + 0.78 | 1.01 + 0.35 | F(3,72) = 0.90; p = 0.44 | |
| S-CE-123 (retroactive) | ||||||
| 3 h | Latency | 2.62 + 0.34 | 3.13 + 0.55 | 4.47 + 1.24 | 6.44 + 1.79 | F(3,80) = 2.25; p = 0.09 |
| Aggression | 2.05 + 0.40 | 1.57 + 0.42 | 2.57 + 0.73 | 1.90 + 0.47 | F(3,80) = 0.63; p = 0.63 | |
| 6 h | Latency | 3.38 + 1.16 | 3.85 + 0.70 | 4.66 + 0.98 | 2.53 + 0.49 | F(3,80) = 1.05; p = 0.38 |
| Aggression | 1.65 + 0.37 | 3.79 + 1.25 | 4.81 + 1.10 | 5.19 + 1.38 | F(3,80) = 2.10; p = 0.11 | |
| S-CE-123 (proactive) | ||||||
| 3 h | Latency | 4.05 + 1.07 | 5.03 + 1.85 | 3.48 + 0.71 | 4.60 + 1.23 | F(3,80) = 0.27; p = 0.84 |
| Aggression | 2.30 + 0.72 | 1.96 + 0.54 | 4.32 + 0.69 | 4.96 + 1.13 | F(3,80) = 2.92; p = 0.03 | |
Experimental subjects were treated with either rac-CE-123 or S-CE-123 30 min before the 1st sampling (when testing retroactive interference) or the 2nd sampling (when testing proactive interference) and subsequently tested as illustrated in Figures 1A,B). The ANOVA results refer to the values of the sample line.