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. 2019 Apr 11;10:379. doi: 10.3389/fphar.2019.00379

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Copyright © 2019 Djillani, Mazella, Heurteaux and Borsotto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure and classification of K_2P channels. The family of K_2P channels is composed of 15 members grouped in six subfamilies. K_2P channels are two-pore domain potassium channels and the most recent class of K⁺ channels discovered. They assemble as dimers of four transmembrane segments (M1–M4) and two-pore domain (P1 and P2). They have an extended M1-P1 extracellular loop and cytosolic N- and C-termini. K_2P channels have a unique pore signature sequence Gly-Tyr(Phe)-Gly in the 1st pore (P1) and Gly-Leu(Phe)-Gly in the 2nd pore (P2).