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. 2019 Apr 17;9:6224. doi: 10.1038/s41598-019-42728-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Microglia make close appositions with hypoglycemia-activated neurons in arcuate nucleus. (A) Confocal imaging of triple fluorescent-labeled section from ARC of hypoglycemic CX₃CR1 ^+/gfp microglia reporter mouse. GFP (green) –microglia; c-FOS (red) –cell nuclei of activated neurons; and neurofilament H (NF-H) (blue) – neurons. (B) Representative images of contacts between NPY neurons (green) and IBA1 positive microglia (red) in hypoglycemic NPY-Ires-Cre ZsGreen reporter mouse line. The appositions between microglia and NPY neurons were revealed in the arcuate nucleus by using merged confocal Z-stack images with orthogonal views XZ and YZ, at 60x magnification. White arrows mark close appositions between microglia and NPY neurons.