Figure 8.

Proinflammatory cytokine IL-1 is associated with insulin-induced hypoglycemia. (A) Relative quantities of hypothalamic Il-1b mRNA of fed and fasted + insulin-injected, wild-type and CX₃CR1^−/− mice (n = 3 per groups). (B) IL-1 a/b knockout animals do not display severe hypoglycemia in response to insulin challenge as do wild type animals. Mean ± SEM blood glucose levels in fed and fasted + insulin treated, wild-type and IL-1 a/b KO mice, 1 h after i.p. injections (n = 3–5). Two-way ANOVA with Bonferroni post hoc test revealed main treatment effect of ^##p < 0.01; main genotype effect: *p < 0.05, **p < 0.01, ***p < 0.001. Fed: fed, saline-injected group; Fasted + Insulin: O/N fasted, insulin-injected group.