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ONOO– and damage cell schematic after the occurrence of HIE generation. After the occurrence of HIE, a large amount of Ca2+ internal flow leads to NOS generates NO, NO, and superoxide O2– generate ONOO–, an excessive amount of ONOO– can also result in an increase of ⋅OH–. ONOO– and ⋅OH– lead to protein changes and degeneration, they also contribute to lipid peroxidation and DNA damage.
