Table 1.

Indications/Contraindications for MACI Transplantation Augmented With Autologous Bone Graft

Indications	Contraindications
Symptomatic, full-thickness osteochondral lesions >2 cm2	Advanced degenerative changes affecting multiple compartments of the knee
Bone deficiency with cavitary defect measuring >8 mm in depth	Uncorrected lower extremity malalignment
Femoral condyle, trochlea, patella, or tibial lesions resulting from osteochondritis dissecans, osteonecrosis, post-traumatic osteochondral defects, or localized osteoarthritis	Uncorrected ligamentous instability
Young, high-demand patients who are not a candidate for arthroplasty	Meniscal insufficiency
BMI <35	Inflammatory arthritis

BMI, body mass index; MACI, matrix-induced autologous chondrocyte implantation.