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. Author manuscript; available in PMC: 2019 Aug 16.
Published in final edited form as: Cell Chem Biol. 2018 Jun 14;25(8):931–940. doi: 10.1016/j.chembiol.2018.05.009

Figure 2. Applications of Engineered Cell-Cell Interactions.

Figure 2.

Non-genetically engineered cell-cell interactions are broadly applicable to a variety of fields. (A) The linking of multiple tissue types in vitro can be applied to tissue engineering. (B) Cytotoxic T cells can be directed to – and subsequently kill – antigen expressing cells for immunotherapy. Alternatively, engineered antigen presenting cells can be used to prime T cells against a particular target. (C) Therapeutic cells can be modified to more efficiently tether, roll, and extravasate through the vasculature, improving their delivery to target tissues. (D) Regenerative stem and progenitor cells can be functionalized with targeting ligands that enhance their accumulation within sites of injury.