Table 3. Association between gene models of CYP3A4 gene locus and hypertension.
| SNP | Model | Control | Case | χ2 | P-value | OR | 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||||
| rs4646437 | A vs G | 258/782 | 24.8/75.2 | 279/621 | 31.0/69.0 | 9.242 | 0.002 | 1.36 | 1.12–1.66 |
| AA vs GA | 41/176 | 18.9/81.1 | 75/129 | 36.8/63.2 | 16.823 | 0.000 | 2.50 | 1.60–3.89 | |
| GA vs GG | 176/303 | 36.7/63.3 | 129/246 | 34.4/65.6 | 0.503 | 0.478 | 0.90 | 0.68–1.20 | |
| AA vs GG | 41/303 | 11.9/88.1 | 75/246 | 23.3/76.7 | 15.106 | 0.000 | 2.25 | 1.49–3.42 | |
| GA + AA vs GG | 217/303 | 41.7/58.3 | 204/246 | 45.3/54.7 | 1.275 | 0.259 | 1.16 | 0.90–1.49 | |
| AA vs GG + GA | 41/479 | 7.8/92.1 | 75/375 | 16.7/83.3 | 17.671 | 0.000 | 2.34 | 1.56–3.50 | |