Table 1.
Uni- and multivariate analysis for MCAK and survival in microarray datasets.
| Data set (cases) | Overall survival | Disease-free survival | |||
|---|---|---|---|---|---|
| HR (95% CI) | Adjusted HR (95% CI)∗ | HR (95% CI) | Adjusted HR (95% CI)∗ | ||
| GSE7390 | |||||
| (n=198) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 2.93 (1.19-8.23)† | 3.14 (1.27-8.84) † | 2.30 (1.21-4.62) † | 2.26 (1.18-4.55) † | |
| Q3 | 4.84 (2.09-13.12) ‡ | 4.89 (1.96-13.94) ‡ | 3.41 (1.82-6.76) ‡ | 3.67 (1.85-7.62) ‡ | |
| Q4 | 2.32 (0.90-6.81) | 1.72 (0.60-5.75) | 1.65 (0.82-3.41) | 1.85 (0.80-4.35) | |
| GSE2034 | |||||
| (n=286) | Q1 | N/A | N/A | Reference | Reference |
| Q2 | 1.56 (0.86-2.89) | 1.55 (0.86-2.88) | |||
| Q3 | 2.13 (1.21-3.87) ‡ | 2.26 (1.27-4.13) ‡ | |||
| Q4 | 2.19 (1.24-4.00) ‡ | 2.47 (1.35-4.62) ‡ | |||
| GSE1456 | |||||
| (n=159) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 10.1 (1.90-187) ‡ | 1.6e+9 | 1.8e+9 | 1.5e+9 | |
| (4.06-2.7e+305) ‡ | (6.03-6.6e+179) ‡ | (4.55-9.0e+304) ‡ | |||
| Q3 | 21.7 (4.46-392) ‡ | 3.1e+9 | 2.9e+9 | 2.2e+9 | |
| (7.91-3.6e+122) ‡ | (9.71-1.5e+254) ‡ | (6.58-1.8e+34) ‡ | |||
| Q4 | 15.2 (3.03-276) ‡ | 1.9e+9 | 2.5e+9 | 1.4e+9 | |
| (4.59-6.9e+100) ‡ | (8.38-6.3e+55) ‡ | (3.81-1.2e+137) ‡ | |||
| GSE4922 | |||||
| (n-289) | Q1 | N/A | N/A | Reference | Reference |
| Q2 | 1.25 (0.65-2.41) | 1.23 (0.63-2.43) | |||
| Q3 | 1.99 (1.08 -3.76)† | 1.82 (0.95-3.56) | |||
| Q4 | 2.33 (1.28-4.36) ‡ | 1.65 (0.79-3.50) | |||
| GSE22226 | |||||
| (n=129) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 0.71 (0.14-3.32) | 0.92 (0.17-4.99) | 0.83 (0.29-2.31) | 0.68 (0.20-2.15) | |
| Q3 | 2.24 (0.70-8.38) | 1.73 (0.47-8.30) | 1.27 (0.49-3.39) | 1.10 (0.39-3.24) | |
| Q4 | 3.94 (1.37-14.1) ‡ | 2.49 (0.71-11.7) | 2.95 (1.30-9.27) ‡ | 2.18 (0.84-6.15) | |
| GSE24450 | |||||
| (n=183) | Q1 | Reference | N/A | Reference | N/A |
| Q2 | 0.60 (0.12-2.44) | 0.50 (0.10-1.89) | |||
| Q3 | 2.07 (0.74-6.66) | 1.86 (0.69-5.47) | |||
| Q4 | 4.29 (1.72-12.9) ‡ | 4.23 (1.80-11.6) ‡ | |||
| GSE53031 | |||||
| (n=167) | Q1 | N/A | N/A | Reference | Reference |
| Q2 | 3.58 (1.30-12.6) † | 2.87 (1.01-10.3) † | |||
| Q3 | 2.88 (1.00-10.3) † | 1.99 (0.66-7.33) | |||
| Q4 | 2.91 (0.99-10.5) | 1.30 (0.39-5.16) | |||
| GSE25066 | |||||
| (n=198) | Q1 | N/A | N/A | Reference | Reference |
| Q2 | 2.13 (0.67-7.84) | 1.62 (0.49-6.25) | |||
| Q3 | 5.03 (1.86-17.49) ‡ | 3.86 (1.33-14.2) † | |||
| Q4 | 4.54 (1.66-15.84) ‡ | 2.55 (0.80-10.1) | |||
| GSE10885 | |||||
| (n=237) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 1.79 (0.70-4.89) | 1.43 (0.49-4.50) | 0.85 (0.35-2.02) | 0.95 (0.36-2.44) | |
| Q3 | 1.75 (0.65-4.91) | 1.21 (0.40-3.79) | 1.95 (0.94-4.22) | 1.75 (0.77-4.17) | |
| Q4 | 2.68 (1.18-6.85) † | 2.01 (0.74-6.13) | 1.97 (0.98-4.13) | 1.77 (0.75-3.47) | |
| GSE58812 | |||||
| (n=107) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 0.73 (0.24-2.10) | 0.83 (0.27-2.42) | 1.39 (0.48-4.22) | 1.54 (0.53-4.70) | |
| Q3 | 1.13 (0.45-2.96) | 1.39 (0.54-3.69) | 1.84 (0.70-5.33) | 2.22 (1.02-7.63) | |
| Q4 | 0.55 (0.17-1.66) | 0.67 (0.20-2.01) | 0.91 (0.29-2.99) | 1.10 (0.34-3.55) | |
| NKI set | |||||
| (n=295) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 3.56 (1.28-12.57) † | 2.64 (0.92-8.48) | 1.87 (0.99-3.70) | 1.60 (0.83-3.21) | |
| Q3 | 9.12 (3.60-30.71) ‡ | 5.47 (2.07-18.9) ‡ | 3.89 (2.17-7.40) ‡ | 2.95 (1.59-5.80) ‡ | |
| Q4 | 11.16 (4.41-37.54)‡ | 4.39 (1.53-16.0) ‡ | 3.95 (2.19-7.55) ‡ | 2.37 (1.17-5.00) † | |
| TCGA1 | |||||
| (n=526) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 0.68 (0.36-1.27) | 0.74 (0.39-1.38) | 1.32 (0.63-2.84) | 1.39 (0.66-3.07) | |
| Q3 | 1.01 (0.55-1.84) | 1.17 (0.63-2.16) | 0.76 (0.30-1.84) | 0.79 (0.30-1.96) | |
| Q4 | 0.94 (0.52-1.70) | 1.01 (0.50-2.02) | 1.67 (0.83-3.51) | 4.25 (0.78-4.25) | |
| TCGA2 | |||||
| (n=1903) | Q1 | Reference | Reference | NA | NA |
| Q2 | 1.99 (1.53-2.61) ‡ | 1.88 (1.43-2.50) ‡ | |||
| Q3 | 2.50 (1.94-3.26) ‡ | 2.08 (1.57-2.78)‡ | |||
| Q4 | 3.00 (2.33-3.89)‡ | 2.20 (1.63-2.99) ‡ | |||
| Pooled GEO | |||||
| (n=2248) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 1.83 (1.22-2.80) ‡ | 2.04 (1.20-3.60) ‡ | 1.64 (1.28-2.11)‡ | 1.54 (1.34-2.09) ‡ | |
| Q3 | 3.55 (2.45-5.27) ‡ | 3.13 (1.87-5.47) ‡ | 2.66 (2.11-3.38)‡ | 2.30 (1.71-3.14) ‡ | |
| Q4 | 3.77 (2.61-5.59)‡ | 2.27 (1.30-4.11) ‡ | 2.66 (2.11-3.38)‡ | 1.82 (1.31-2.54)‡ | |
| Pooled TCGA | |||||
| (n=2429) | Q1 | Reference | Reference | Reference | Reference |
| Q2 | 1.71 (1.35-2.19) ‡ | 1.85 (1.41-2.45) ‡ | 1.32 (0.63-2.84) | 1.40 (0.66-3.07) | |
| Q3 | 2.18 (1.73-2.77) ‡ | 2.08 (1.57-2.77) ‡ | 0.76 (0.30-1.84) | 0.79 (0.30-1.96) | |
| Q4 | 2.55 (2.03-3.22)‡ | 2.22 (1.65-3.01) ‡ | 1.67 (0.83-3.51) | 1.79 (0.78-4.25) | |
Note: uni- and multivariate analyses were conducted to evaluate HR of MCAK.
∗For multivariate analysis, HR was adjusted by age, ER status, and Elston Grade in GSE7390, GSE4922, and GSE25066 and in pool analysis datasets. In the GSE2034 set, HR was adjusted by ER status and it was adjusted by age and ER status in GSE58812. The probe of MCAK was 209408_s_at.
HR was adjusted by age, ER status, and Elston Grade in GSE10885 and GSE22226 sets, in which the probe of MCAK was A_23_P34788.
The probe of MCAK was ILMN_1779153 in GSE24550.
HR was adjusted by age, ER status, and Elston Grade in the GSE53031 set, in which the probe of MCAK was 11745868_a_at.
∗† Statistical significance, P<0.05; ‡ Statistical significance, P<0.01.