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. 2019 Apr 3;2019:8215017. doi: 10.1155/2019/8215017

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Copyright © 2019 Ewelina Palasz et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of MPTP and treadmill training on the brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) level in the midbrain and striatum. Immunohistochemical staining against BDNF (a) and GDNF (b) in the substantia nigra pars compacta (SNpc), quantitative analysis of BDNF and GDNF in the midbrain (c, d), and striatum (e, f). C: control; CTT: control + treadmill training; M: treatment with MPTP; METT: MPTP + early onset treadmill training; MLTT: MPTP + late-onset treadmill training group. Scale bar: 100 μm. Statistical comparisons were performed with one-way ANOVA followed by Newman-Keuls post hoc test; ^∗∗p < 0.001, ^∗p < 0.05.