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. 2019 Mar 14;20(6):1285. doi: 10.3390/ijms20061285

Figure 5.

Figure 5

Dose curve experiments confirm that Obatoclax can cause the decreased expression of cyclin D1 and Cdk4/6. Treatment with Obatoclax caused dose-dependent reductions in the expression of cyclin D1 in TCCSuP and 5637 cells. In T24 cells, the highest dose of Obatoclax (80 nM) caused a slight reduction in cyclin D1 expression. A clear dose-dependent reduction in Cdk6 expression levels was observed in all three cell lines, while dose-dependent reductions in Cdk4 expression levels were observed in T24 and 5637 cells. (Veh = vehicle control, Cis = cisplatin).