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. 2019 Mar 23;24(6):1154. doi: 10.3390/molecules24061154

Table 1.

Structures and inhibition effects of target compounds on IL-1β release activities.

graphic file with name molecules-24-01154-i009.jpg

No. R Inhibitory Rate % a No. R Inhibitory Rate %
1 CH3 40.7 5b graphic file with name molecules-24-01154-i005.jpg 80.5
2 H 50.5 6 - 76.1
3a CH3CH2 35.5 7 H 19.9
3b CH3CH2CH2 71.8 8a C6H5CO 87.0
3c (CH3)2CHCH2 46.8 8b p-CH3C6H4CO 51.4
3d CH3CH2OCH2CH2 37.4 8c p-OCH3C6H4CO 48.8
3e graphic file with name molecules-24-01154-i001.jpg 67.4 8d (3,4,5)-(OCH3)3C6H2CO 35.4
3f graphic file with name molecules-24-01154-i002.jpg 66.0 8e p-NO2C6H4CO 54.6
3g C6H5CH2 80.8 8f p-ClC6H4CO 77.5
3h graphic file with name molecules-24-01154-i003.jpg 69.3 8g graphic file with name molecules-24-01154-i006.jpg 55.2
4a CH3CH2CO 44.8 8h graphic file with name molecules-24-01154-i007.jpg 39.4
4b CH3(CH2)2CO 57.7 8i graphic file with name molecules-24-01154-i008.jpg 69.6
4c CH3(CH2)3CO 54.6 8j (3,4)-(Cl)2C6H4CO -
4d (CH3)2CHCO 52.3 8k C6H5SO2 -
4e (CH3)3CCH2CO 72.1 8l p-CH3OC6H5SO2 -
5a graphic file with name molecules-24-01154-i004.jpg 69.9 8m p-CH3C6H5SO2 -

a The ELISA analysis of IL-1β in culture supernatants of PMA primed THP-1 cells treated with target compounds (5 μM) and then stimulated with LPS (5 µg/mL) and NIG (20 µM).