Table 3.
Inhibition of viral replication and reduction in cell viability.
| Cells | Compound | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UT7 | 2hpi | 48hpi | DMSO | 1a | 2a | 6 | 7 | 1b | 2b | 8 | 9 | 10 |
| Log B19V Copies a | 5.03 | 7.02 | 7.16 | 6.61 | 6.89 | 7.06 | 6.41 | 7.11 | 7.13 | 6.97 | 6.69 | 6.78 |
| Delta Log b | 1.99 | 2.13 | 1.58 | 1.86 | 2.03 | 1.38 | 2.08 | 2.09 | 1.94 | 1.66 | 1.74 | |
| % viral replication c | 73.73 | 100.00 | 28.41 | 53.59 | 79.99 | 17.87 | 88.96 | 92.07 | 65.04 | 34.16 | 41.38 | |
| % cell viability c | 97.87 | 100.00 | 70.85 | 100.59 | 108.34 | 70.77 | 93.35 | 107.24 | 96.74 | 60.10 | 68.54 | |
| Ratio v/r d | 1.36 | 1.00 | 2.49 | 1.88 | 1.35 | 3.99 | 1.05 | 1.16 | 1.49 | 1.77 | 1.66 | |
| EPCs | 2hpi | 48hpi | DMSO | 1a | 2a | 6 | 7 | 1b | 2b | 8 | 9 | 10 |
| Log B19V Copies a | 5.02 | 7.37 | 7.37 | 7.10 | 7.26 | 7.51 | 7.12 | 7.40 | 7.16 | 6.91 | 7.04 | 7.15 |
| Delta Log b | 2.35 | 2.35 | 2.08 | 2.23 | 2.49 | 2.09 | 2.38 | 2.13 | 1.89 | 2.01 | 2.13 | |
| % viral replication c | 100.36 | 100.00 | 54.05 | 76.87 | 137.83 | 55.76 | 108.13 | 60.92 | 34.96 | 46.18 | 60.43 | |
| % cell viability c | 112.41 | 100.00 | 53.92 | 87.09 | 91.14 | 74.43 | 88.10 | 96.20 | 82.78 | 54.43 | 82.53 | |
| Ratio v/r d | 1.12 | 1.00 | 1.00 | 1.13 | 0.66 | 1.34 | 0.82 | 1.58 | 2.39 | 1.18 | 1.37 | |
a Log B19V genome copies/104 cells; b increase respective to 2 hpi sample; c compared to 1% DMSO (48 hpi); d ratio of % cell viability to % viral replication.