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. 2019 Mar 20;24(6):1108. doi: 10.3390/molecules24061108

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of compound 3f against small mothers against decapentaplegic homologs (Smad) signaling. (A) 3f inhibited cytoplasm to nuclear translocation of Smad2/3 in MRC-5 cells. Immunofluorescence staining using an antibody recognizing total Smad2 and Smad3. Red arrows indicate the localization of Smad2/3 in cytoplasm, and white arrows indicate the nuclear localization of Smad2/3; (B) 3f inhibited TGF-β1-induced upregulation of expression level of TGF-β receptor type I (TGFβRI); (C) mean fluorescence intensity (MFI) of TGFβRI, presented as mean ± SD of three individual experiments. * p < 0.05 vs. TGFβ group, ^# p < 0.05 vs. DMSO group.