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Uric acid (UA) prevents OONO effect on (A) ASCT1 and (B) B0AT1 activity. SIN-1 treatment significantly decreased ASCT1 and B0AT1 activities in IEC-18 cells. Uric acid (1 mM) pretreatment prevented the effect of SIN-1 treatment on both Na-amino acid co-transporters’ activities in IEC-18 cells. Thus, these data demonstrate that the inhibition of ASCT1 and B0AT1 activity was due to peroxynitrite produced from SIN-1 treatment.
