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. 2019 Mar 14;20(6):1283. doi: 10.3390/ijms20061283

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CAR T cells mediate tumor killing via three axes: (1) Perforin and granzyme axis: Targeting antigen positive fraction. (2) Cytokine secretion: Stromal cell sensitization. (3) Fas and FasL axis: Targeting antigen-negative fraction.