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. 2019 Mar 21;20(6):1444. doi: 10.3390/ijms20061444

Figure 7.

Figure 7

The sequence alignment of mouse, Bacillus cereus and Rhodobacter sphaeroides TSPO: The boxes depict the five transmembrane domains (labelled TM1 to TM5) as well as the short alpha helix in continuity with the first TM for BcTSPO and RsTSPO. The black bold amino acids are those involved in the transmembrane helices in the NMR atomic structure obtained from (mTSPO—PDB-2MGY). The amino acids involved in the PK 11195 binding pocket of the atomic structure obtained either from NMR (mTSPO—PDB-2MGY) or x-ray (BcTSPO—PDB-4RYI) data are written in red bold characters. Those involved in the protoporphyrin IX (PPIX) binding pocket of the atomic structure from the x-ray data of RsTSPO (PDB-4UC1) are in green.