Table 1.

Summary of crystal structures for the 7TM domain of mGlu receptors.

Receptor	PDB ID	Method	Resolution	Description	Reference
mGlu1	4OR2	X-ray diffraction	2.8 Å	Crystal structure of 7TM domain of human mGlu1 bound to FITM (NAM). Soluble cytochrome b562 present for stabilization.	[17]
mGlu5	4OO9	X-ray diffraction	2.6 Å	Structure of the human 7TM domain of mGlu5 bound to mavoglurant (NAM). Lysozyme used for stabilization.	[16]
	5CGC	X-ray diffraction	3.1 Å	Structure of human 7TM domain of mGlu5 bound to 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile (NAM). Endolysin present in the structure used for stabilization.	[18]
	5CGD	X-ray diffraction	2.6 Å	Structure of human 7TM of mGlu5 bound to HTL14242 (NAM). Endolysin present in the structure used for stabilization.	[18]
	6FFH	X-ray diffraction	2.7 Å	Crystal structure of 7TM domain of human mGlu5 bound to fenobam (NAM). Endolysin present in the structure for stabilization.	[19]
	6FFI	X-ray diffraction	2.2 Å	Crystal structure of 7TM domain of human mGlu5 bound to M-MPEP (NAM). Endolysin present for stabilization.	[19]