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. 2019 Mar 13;20(6):1259. doi: 10.3390/ijms20061259

Figure 3.

Figure 3

The effect of four anti-seizure drugs on EV-related genes in cell lines. The gene expression profiles of the anti-seizure drugs were downloaded from the LINCS database and used to prepare a rank lists for the Gene Set Enrichment Analysis. The top100 EV-related proteins from Vesiclepedia (http://microvesicles.org/, accessed on: 1 December 2018) were used as a gene set. (A) EV-related genes were negatively enriched by carbamazepine in the HCC, RMUGS, and THP1 cell lines. (B) Primidone treatment induced a negative enrichment in the HA1E cell line and a positive enrichment in the PC3 cell line. (C) Gabapentin treatment induced a negative enrichment. (D) Lamotrigine treatment did not show any enrichment of genes. ES, enrichment score; FDR, false discovery rate; HCC, Hepatocellular carcinoma cell line; HA1E, Cellosaurus cell line; PC3, human prostate cancer cell line; VCAP, human prostate cancer cell line; RMUGS, Cellosaurus cell line; THP1, human leukemic monocyte cell line.