Table 2.
Pharmacokinetic parameters for different CBZ formulations with a dose of 15 mg/kg cabazitaxel after tail vein injection. Data are presented mean ± SD (n = 6).
| Parameter | Micellar Solution | NPs | Liposomes |
|---|---|---|---|
| Cmax (ng/mL) | 16,075.5 ± 4.12 | 8858.05 ± 2.02 *** | 7959.3 ± 1.07 *** |
| Tmax (h) | 0.083 ± 0.05 | 0.083 ± 0.07 | 0.083 ± 0.05 |
| AUCtot (ng·h/L) | 15,008.42 ± 12.51 | 6902.48 ± 2.15 *** | 14,223.0 ± 2.07 *** |
| t1/2 (h) | 1.828 ± 0.05 | 2.583 ± 0.12 *** | 7.585 ± 0.09 *** |
| MRT (h) | 1.856 ± 0.07 | 2.485 ± 0.05 *** | 8.882 ± 0.17 *** |
Cmax: maximum peak plasma concentration, Tmax: time at which the peak plasma concentration was obtained, AUCtot: total area under the curve after drug absorption, t1/2: half-life of the drug, MRT: mean residence time of the drug. Micellar solution vs. NPs, micellar solution vs. liposomes, and NPs vs. liposomes (*** p < 0.001).