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Temporal profiles of plasma concentrations of (A) PA and (B) NAPA, and the cumulative urinary excretions of (C) PA and (D) NAPA, after 10 mg/kg dose of PA HCl in rats, in the absence or presence of cimetidine (10 min before PA administration). Closed and open circles represent results observed without (control) or with cimetidine. Symbols represent the mean ± S.D (n = 4, for each group).
