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. 2019 Mar 6;11(3):108. doi: 10.3390/pharmaceutics11030108

Figure 3.

Figure 3

Effects of cimetidine on the metabolic conversion of PA to NAPA using in vitro rat liver S9 fraction. (A) Dependence of the metabolic conversion rate on the PA concentration in rat liver S9 fractions (50, 500, and 5000 μM) (n = 5 for each column) (B) Inhibitory effects of cimetidine on the conversion rate of PA to NAPA in rat liver S9 fractions (three independent experiments with triplicate measurement) (n = 3 for each point). Symbols represent the mean ± S.D.