Table 5.

Tissue-to-plasma concentration ratio at steady state ($K_{p,ss}$) of PA and NAPA for 6 major tissues (n = 5 for each group).

Tissue	PA		NAPA
	Control (without Cimetidine)	Co-Treatment (with Cimetidine)	Control (without Cimetidine)	Co-Treatment (with Cimetidine)
Brain	0.200 ± 0.0208	0.246 ± 0.0584	0.713 ± 0.0204	0.0893 ± 0.0710 **
Heart	3.45 ± 1.19	1.80 ± 0.821 *	12.7 ± 2.55	2.40 ± 0.728 **
Kidney	5.68 ± 2.01	9.71 ± 2.30	21.0 ± 5.95	12.5 ± 2.87 *
Liver	2.86 ± 2.11	0.844 ± 0.254	17.8 ± 7.00	6.89 ± 2.68 *
Lung	2.52 ± 1.10	0.547 ± 0.202 **	9.68 ± 2.56	2.65 ± 0.499 **
Spleen	1.34 ± 0.424	1.49 ± 0.590	7.60 ± 1.52	4.69 ± 1.90 *

* p < 0.05 and ** p < 0.001 compared with control rats.