Figure 4.

Schematic representation of glycolysis, pentose phosphate pathways (PPP) and TCA cycle. This clarifies how glycolysis was induced by treatment that increases ATP generation. Included column figures demonstrate average metabolite intensity in different groups. Glucose flux into oxidation PPP reflects the impact of TSPO knockout and oxLDL treatment in RPE cells. NADPH provides insight into the redox status of cells, while various factors play an important role in its synthesis and consumption. * Indicates that difference is significant with corrected p < 0.05. KOT: TSPO knockout cells with the treatment of oxLDL; KOC: TSPO knockout cells without the treatment of oxLDL; WTT: Wildtype cells with the treatment of oxLDL; WTC: Wildtype cells without the treatment of oxLDL. Error bar is the standard error of the mean (SEM).