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. 2019 Mar 19;20(6):1387. doi: 10.3390/ijms20061387

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Oxidized glutathione (GSSG) converts to its reduced form in the presence of NADPH, which donates a proton and is converted to its oxidized form, NADP+. GSSG increased significantly when knockout cells were treated by oxLDL. GSH: glutathione; GSSG: glutathione disulphide; GR: glutathione reductase; GPx: glutathione peroxidase. KOT: TSPO knockout cells with the treatment of oxLDL; KOC: TSPO knockout cells without the treatment of oxLDL; WTT: Wildtype cells with the treatment of oxLDL; WTC: Wildtype cells without the treatment of oxLDL. * Indicates that difference is significant with p < 0.05. Error bar is the standard error of the mean (SEM).