Figure 1.

Gene interaction networks created in GeneMania for selected genes. The relations between the chosen genes based on their known participation in female reproduction and metabolism (query genes, striped circles) and additionally automatically generated genes mediating in the biological processes (interacting genes, non-striped circles). Colours on the circles indicate the contribution of the genes in the specific biological functions. The size of the circle indicates the importance of the gene in the specific interactions. The colour of the lines connecting the genes denotes the type of interaction: co-expression (A), co-localization and pathways (B), as well as physical interactions and shared protein domains (C), while the width of lines indicates the weight of interaction between genes (refer to the key).