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Cumulative release profile of DOX from SPION@HP (●) at predetermined time intervals. Each marked point corresponds to 0, 1, 3, 6, 12, 24, 36, 48, 72, 96, and 120 h. The release of free DOX (▲) was carried out as a control, in which the amount of free DOX was equivalent to the amount of loaded DOX in the SPION@HP. All experiments were performed three times in PBS (0.01 M) at 37 °C.
