Table 4.
Changes in serum 25(OH)D levels after intervention supplementation.
| References | Within Group Differences | Between Group Differences |
|---|---|---|
| [19] | Intervention: 20,000 IU of vitamin D significantly increased serum 25(OH)D levels from a mean of 55.56 to 123.17 nmol/L. Control: there was only a minor increase from 57.33 to 61.80 nmol/L. | Significant difference in serum levels of 25(OH)D after 96 weeks between the intervention and control groups (p < 0.001). |
| [21] | n/a | n/a |
| [12] | Intervention: serum 25(OH)D levels significantly increased in a high-dose (4370 IU/d) groups from a mean of 48.2 to 122.6 nmol/L Control: low-dose (800 IU/d) from 48 to 68 nmol/L. | Significantly higher serum 25(OH-D) levels were reported in high dose group compared to low-dose arm after 48 weeks (p < 0.001). |
| [14] | Intervention: serum 25(OH)D levels increased significantly from a mean of 54 to 109 nmol/L. Placebo: decreased from a mean of 55 to 51 nmol/L after 48 weeks. | n/a |
| [16] | Intervention: Serum 25(OH)D levels rose from a median of 28.27 to 84.67 nmol/L. Placebo: fell from 39.6 to 28.66 nmol/L. | A significant difference after 12 weeks between groups (p < 0.001). |
| [15] | Intervention: serum levels of 25(OH)D significantly increased from 56 to 123nmol/L. Placebo: levels slightly increased from 57 to 63 nmol/L. | A significant difference in serum levels after 96 weeks between groups (p < 0.001). |
| [18] | Intervention: serum 25(OH)D levels significantly increased from a median of 28.27 to 84.67 ng/mL. Placebo: a decrease from 39.6 to 28.66 ng/mL. | These differences were significant between groups after 12 weeks (p < 0.001). |
| [17] | Intervention: serum 25(OH)D concentration increased significantly in the vitamin D group from 60 to 231 nmol/L. Placebo: changed to a lesser degree (54 to 60 nmol/L). | The was a significant difference after 48 weeks between the groups (p < 0.001). |
| [13] | High dose: Mean change of 34.9 ng/mL. Low dose: mean change of 6.9 ng/mL | A high dose of vitamin D resulted in significantly higher serum 25(OH-D) levels versus low-dose after 24 weeks (p < 0.00001). |
| [20] | Intervention: serum 25(OH)D levels increased from a mean of 54 to 110 nmol/L. Placebo: decreased from a mean of 56 to 50 nmol/L after 48 weeks | A significant difference between groups (p < 0.001). |