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The major binding modes of BRACO19 in complex with the human telomeric DNA. (A) Duplex; (B) Parallel G-quadruplex; (C) Anti-parallel human telomeric G-quadruplex; (D) Hybrid human telomeric G-quadruplex. (A–D) Top binding (left), Bottom binding (middle) and groove binding (right); 5′ end and 3′ end are represented by the red and blue ball respectively.
