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. 2019 Mar 21;19(5):4195–4204. doi: 10.3892/mmr.2019.10074

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Helios⁺ Tregs promote angiogenesis through the VEGFA/VEGFR2 pathway in a mouse model of acute lymphoblastic leukemia. (A) Western blot and quantitative analyses of VEGFA, VEGFR2 and p-VEGFR2 proteins in the BM of the blank, model, Helios^high and Helios^low groups. (B) Quantitative analyses of the CD31 MVD values of the BM in the blank, model, Helios^low and Helios^high groups. (C) Quantitation of the mRNA expression of CCL22 in the BM of the blank, model, Helios^low and Helios^high groups. (D) Quantitation of the protein levels of CCL22 in the plasma of the blank, model, Helios^low and Helios^high groups. (***P<0.0005, **P<0.005, *P<0.05). VEGF, vascular endothelial growth factor; VEGFR2, VEGF receptor 2; p-VEGFR2, phosphorylated VEGFR2; MVD, microvascular density; BM, bone marrow; CCL2, CC-chemokine ligand 22.