Table 3.
Compound Number | IC50 (Mean ± SEM) (µM) |
---|---|
DHFR | |
1 | 17.26 ± 0.43 |
2 | 14.33 ± 0.81 |
3 | 28.54 ± 0.22 |
4 | 31.57 ± 0.30 |
5 | 15.38 ± 0.12 |
6 | 13.45 ± 0.23 |
8 | 20.54 ± 0.14 |
9 | 8.46 ± 0.13 |
10 | 1.00 ± 0.85 |
11 | 17.13 ± 0.90 |
12 | 36.48 ± 0.72 |
13 | 0.09 ± 0.91 |
14 | 0.08 ± 0.37 |
15 | 0.04 ± 0.82 |
16 | 10.24 ± 0.97 |
17 | 27.42 ± 0.35 |
18 | 24.71 ± 1.26 |
19 | 29.00 ± 1.25 |
20 | 11.80 ± 0.79 |
Methotrexate | 0.14 ± 1.38 |
IC50: Compound concentration required to inhibit DHFR enzyme activity by 50%, SEM = standard error mean; each value is the mean of three values.