Table 1.
Left ventricular wall thickness and functional analysis of Wt and Cre+ animals. Left ventricle analysis on Wt and Cre+ mice from ECHO studies from 3 to 8 months of age. Functional analysis was done via measurements of left ventricle wall sizes and interdiameters during diastole and systole.
| 3 months | Wt | Cre+ | p-value | 4 months | Wt | Cre+ | p-value |
| IVS;d (mm) | 0.630 ± 0.025 | 0.620 ± 0.027 | 0.291692478 | IVS;d (mm) | 0.645 ± 0.028 | 0.675 ± 0.033 | 0.788462538 |
| IVS;s (mm) | 0.841 ± 0.024 | 0.752 ± 0.042 | 0.088168344 | IVS;s (mm) | 0.840 ± 0.031 | 0.799 ± 0.006 | 0.063367682 |
| LVID;d (mm) | 3.988 ± 0.120 | 3.891 ± 0.062 | 0.844773361 | LVID;d (mm) | 3.945 ± 0.130 | 3.816 ± 0.170 | 0.854738647 |
| LVID;s (mm) | 2.965 ± 0.104 | 3.062 ± 0.078 | 0.533414051 | LVID;s (mm) | 2.983 ± 0.210 | 2.923 ± 0.180 | 0.816015832 |
| LVPW;d (mm) | 0.752 ± 0.039 | 0.703 ± 0.009 | 0.421564695 | LVPW;d (mm) | 0.741 ± 0.033 | 0.692 ± 0.031 | 0.163169522 |
| LVPW;s (mm) | 0.950 ± 0.058 | 0.865 ± 0.023 | 0.186036258 | LVPW;s (mm) | 0.917 ± 0.021 | 0.903 ± 0.052 | 0.612779363 |
| EF (%) | 51.078 ± 1.225 | 43.930 ± 1.415 | 0.050885727 | EF (%) | 49.190 ± 4.900 | 47.703 ± 2.932 | 0.626142978 |
| FS (%) | 25.670 ± 0.730 | 21.351 ± 0.789 | 0.040507965 | FS (%) | 24.692 ± 2.920 | 23.568 ± 1.676 | 0.592817029 |
| LV Mass (mg) | 77.478 ± 6.617 | 69.760 ± 0.624 | 0.462915868 | LV Mass (mg) | 76.123 ± 4.930 | 70.596 ± 4.086 | 0.474495439 |
| LV Vol;d (µL) | 69.792 ± 4.975 | 65.625 ± 2.444 | 0.828743538 | LV Vol;d (µL) | 68.114 ± 5.262 | 63.086 ± 6.373 | 0.875915463 |
| LV Vol;s (µL) | 34.230 ± 2.917 | 36.890 ± 2.231 | 0.540609259 | LV Vol;s (µL) | 35.345 ± 5.924 | 33.372 ± 4.70 | 0.832144194 |
| Heart Rate (bpm) | 475.063 ± 31.085 | 426.813 ± 25.030 | 0.24795013 | Heart Rate (bpm) | 442.375 ± 15.083 | 488.813 ± 18.431 | 0.131686783 |
| 5 months | Wt | Cre+ | p-value | 6 months | Wt | Cre+ | p-value |
| IVS;d (mm) | 0.703 ± 0.055 | 0.621 ± 0.033 | 0.221718131 | IVS;d (mm) | 0.645 ± 0.0270 | 0.623 ± 0.025 | 0.582227989 |
| IVS;s (mm) | 0.867 ± 0.037 | 0.760 ± 0.032 | 0.066845485 | IVS;s (mm) | 0.770 ± 0.046 | 0.773 ± 0.036 | 0.944541382 |
| LVID;d (mm) | 4.015 ± 0.070 | 4.24 ± 0.022 | 0.011199612 | LVID;d (mm) | 3.860 ± 0.086 | 4.267 ± 0.050 | 0.000984789 |
| LVID;s (mm) | 3.010 ± 0.094 | 3.428 ± 0.029 | 0.007459428 | LVID;s (mm) | 3.111 ± 0.115 | 3.480 ± 0.073 | 0.015556863 |
| LVPW;d (mm) | 0.771 ± 0.045 | 0.720 ± 0.019 | 0.292980414 | LVPW;d (mm) | 0.741 ± 0.013 | 0.670 ± 0.022 | 0.037445862 |
| LVPW;s (mm) | 0.941 ± 0.033 | 0.853 ± 0.036 | 0.123190118 | LVPW;s (mm) | 0.881 ± 0.058 | 0.840 ± 0.038 | 0.533692627 |
| EF (%) | 46.214 ± 3.352 | 39.801 ± 0.561 | 0.070796387 | EF (%) | 40.113 ± 4.339 | 38.503 ± 2.380 | 0.728792586 |
| FS (%) | 22.836 ± 2.019 | 19.160 ± 0.307 | 0.081406368 | FS (%) | 19.377 ± 2.510 | 18.545 ± 1.313 | 0.75158218 |
| LV Mass (mg) | 85.180 ± 7.413 | 82.324 ± 3.134 | 0.711666602 | LV Mass (mg) | 73.251 ± 2.367 | 79.583 ± 3.594 | 0.228762289 |
| LV Vol;d (µL) | 70.721 ± 2.901 | 80.372 ± 0.981 | 0.010393045 | LV Vol;d (µL) | 64.510 ± 3.442 | 81.820 ± 2.206 | 0.000959293 |
| LV Vol;s (µL) | 38.018 ± 2.791 | 48.402 ± 0.994 | 0.006305021 | LV Vol;s (µL) | 38.590 ± 3.453 | 50.370 ± 2.421 | 0.015009289 |
| Heart Rate (bpm) | 468.229 ± 19.224 | 437.563 ± 22.691 | 0.470433394 | Heart Rate (bpm) | 456.333 ± 23.479 | 457.083 ± 21.667 | 0.985755943 |
| 7 months | Wt | Cre+ | p-value | 8 months | Wt | Cre+ | p-value |
| IVS;d (mm) | 0.652 ± 0.046 | 0.530 ± 0.017 | 0.004871736 | IVS;d (mm) | 0.672 ± 0.038 | 0.525 ± 0.020 | 0.002876701 |
| IVS;s (mm) | 0.852 ± 0.075 | 0.655 ± 0.028 | 0.004820388 | IVS;s (mm) | 0.897 ± 0.038 | 0.583 ± 0.023 | 2.01935E-05 |
| LVID;d (mm) | 4.153 ± 0.107 | 4.710 ± 0.085 | 0.00075479 | LVID;d (mm) | 3.992 ± 0.087 | 5.0120 ± 0.733 | 0.002527764 |
| LVID;s (mm) | 3.100 ± 0.078 | 4.015 ± 0.146 | 0.000380906 | LVID;s (mm) | 2.911 ± 0.181 | 4.613 ± 0.218 | 0.000506287 |
| LVPW;d (mm) | 0.731 ± 0.035 | 0.612 ± 0.0260 | 0.010122283 | LVPW;d (mm) | 0.729 ± 0.043 | 0.607 ± 0.029 | 0.037276373 |
| LVPW;s (mm) | 0.960 ± 0.063 | 0.735 ± 0.033 | 0.001783791 | LVPW;s (mm) | 0.899 ± 0.048 | 0.658 ± 0.047 | 0.009337212 |
| EF (%) | 50.140 ± 2.792 | 31.463 ± 3.171 | 0.000971708 | EF (%) | 53.049 ± 5.311 | 17.836 ± 4.746 | 0.001064173 |
| FS (%) | 25.264 ± 1.830 | 14.966 ± 1.571 | 0.000618349 | FS (%) | 27.203 ± 3.350 | 8.287 ± 2.190 | 0.000655345 |
| LV Mass (mg) | 83.423 ± 9.092 | 80.60 ± 2.389 | 0.667096037 | LV Mass (mg) | 78.378 ± 3.758 | 90.433 ± 6.474 | 0.242979928 |
| LV Vol;d (µL) | 76.765 ± 4.640 | 103.311 ± 4.489 | 0.001168324 | LV Vol;d (µL) | 69.821 ± 3.655 | 120.755 ± 9.005 | 0.00328618 |
| LV Vol;s (µL) | 38.055 ± 2.364 | 71.912 ± 6.740 | 0.002004722 | LV Vol;s (µL) | 33.135 ± 5.253 | 100.210 ± 10.261 | 0.001357712 |
| Heart Rate (bpm) | 458.750 ± 33.700 | 488.292 ± 20.507 | 0.509364526 | Heart Rate (bpm) | 426.833 ± 45.470 | 503.890 ± 12.685 | 0.308473653 |
IVS: Interventricular septum; LVID: Left ventricular interdiameter; LVPW: Left ventricular posterior wall; EF: Ejection fraction; FS: Fractional shortening; LV mass: Left ventricular mass; LV volume: Left ventricular volume; d/s: Diastole/systole. Here, n = 8.